Researchers from Kanazawa University have synthesised a radiotheranostic system with astatine (At-211) as the alpha-particle emitter and iodine (I-123) as the gamma-radiation source.
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For about 90 percent of men with prostate cancer, the cancer remains localised to the primary site, resulting in a five-year survival rate of almost 100 percent. A recent report indicates that a significantly lower presence of syntaphilin (SNPH) – a mitochondrial protein within the tumour’s central core versus at the tumour’s invasive outer edge, may identify patients at increased risk of metastasis.
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A new study finds that the protein responsible for the crawling movements of cells also drives the ability of cancer cells to grow when under stress. The protein is actin, which is also a key component of the contraction apparatus of muscles throughout the body. The link between cell movement and signalling is through the cell’s actin cytoskeleton – chains of actin that dynamically assemble and disassemble to aid locomotion in cancerous and noncancerous cells.
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High-grade serous ovarian cancer (HGSOC) is the most common and aggressive subtype of ovarian cancer. The HGSOC tumours consist of several heterogeneous cell populations with a large number of mutations. This genetic variability makes it difficult to find drugs that would kill all the cancer cells, and to which the cells would not become resistant during treatment. Over half of the patients diagnosed with high-grade serous ovarian cancer die within five years of diagnosis, that is, annually more than 150 000 women globally.
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Cervical cancer is a major issue in low- and middle-income countries due to the lack of adequate screening such as routine Pap smear testing. These countries have high incidences of cervical cancer linked to human papillomavirus (HPV). Due to lack of resources for cancer screenings, these countries account for 85 percent of all cervical cancer cases.
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Foundational research by a City of Hope physician-scientist and his colleagues could one day help metastatic colorectal cancer patients decide whether to choose immunotherapy or chemotherapy as their first treatment option.
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A research team led by investigators at Massachusetts General Hospital (MGH) and the Massachusetts Institute of Technology (MIT) has found that combining a specialised version of an anti-hypertension drug with immune checkpoint blockers could increase the effectiveness of cancer immunotherapies.
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Urine testing may be as effective as the smear test at preventing cervical cancer, according to a study published in the journal BMJ Open.
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A team of researchers has discovered an unexpected relationship between levels of the amino acid leucine and the development of tamoxifen resistance in ER breast cancer.
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Cervical cancer negative for the human papilloma virus (HPV) is rare but more aggressive: it is more frequently diagnosed at advanced stages, with more metastasis and reduced survival. These conclusions are published in Modern Pathology. The study was co-led by ISGlobal, an institution supported by “la Caixa”, the Hospital Clinic and the University of Barcelona.
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