Cancer

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Test for oesophageal cancer could save millions of lives

Cancer of the oesophagus claims more than 400,000 lives around the world each year. With no efficient, reliable method of screening for the disease, by the time symptoms become apparent, it’s often too late to save the patient.

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Gene changes may predict breast cancer relapse

Scientists have identified genetic changes that may predict the likelihood of breast cancer relapse in women taking a common type of hormone therapy.

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Molecular profiling could catch lung cancer early and lead to new treatments

The world’s first genetic sequencing of precancerous lung lesions could pave the way for very early detection and new treatments, reports a new study led by UCL researchers.

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Energising the immune system to attack and eat cancer cells

Immune cells called macrophages are supposed to serve and protect, but cancer has found ways to put them to sleep. Now researchers at the Abramson Cancer Centre of the University of Pennsylvania say they’ve identified how to fuel macrophages with the energy needed to attack and eat cancer cells.

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New nanoparticle flips switch for tumour-infiltrating immune cell

Immunotherapy’s promise in the fight against cancer drew international attention after two scientists won a Nobel Prize this year for unleashing the ability of the immune system to eliminate tumour cells.

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Study of mutation order may change understanding of how tumours develop

Cancers most commonly arise because of a series of two to five mutations in different genes that combine to cause a tumour. Evidence from a growing number of experiments focused on truncal mutations – the first mutations in a given sequence–suggests a new direction in understanding the origins of cancer.

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Scientists create a renewable source of cancer-fighting T cells

A study by UCLA researchers is the first to demonstrate a technique for coaxing pluripotent stem cells – which can give rise to every cell type in the body and which can be grown indefinitely in the lab – into becoming mature T cells capable of killing tumour cells.

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No substantial benefit from transplantation reported for a high-risk leukaemia subtype

Checking for minimal residual disease early in treatment can help some young high-risk leukaemia patients avoid bone marrow transplantation without compromising their long-term survival.

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Scientist identifies gene responsible for spread of prostate cancer

A Rutgers study has found that a specific gene in cancerous prostate tumours indicates when patients are at high-risk for the cancer to spread, suggesting that targeting this gene can help patients live longer.

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New study identifies specific obesity-related risk factors for kidney cancer

A new study confirms the long-suspected role of obesity as a risk factor for developing renal cell carcinoma (RCC), a type of kidney cancer, and identifies several specific obesity-related factors.

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