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Dr Amelie Hofmann-Werther
Dr Amelie Hofmann-Werther
Dr Hofmann-Werther is a Specialist Gynaecology and Obstetrics, Fetal Medicine Sonographer, Psychosomatics and Verbal Intervention Counselor, colposcopist, CBD surgeon, Conference Organization Team, Scientific Committee and Advisory Board Member OBFEGYN.
Dr Amelie Hofmann-Werther
Dr Amelie Hofmann-Werther
Dr Amelie Hofmann-Werther
Dr Hofmann-Werther is a Specialist Gynaecology and Obstetrics, Fetal Medicine Sonographer, Psychosomatics and Verbal Intervention Counselor, colposcopist, CBD surgeon, Conference Organization Team, Scientific Committee and Advisory Board Member OBFEGYN.

Truffle Hunting: It’s all about the right chemistry! Or – metaphorically speaking, “love is in the air.”

Dr Amelie Hofmann-Werther discusses the chemistry of love highlighting including the science behind pheromones.

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1. Darwin, C. 1859. The origin of species. London, Penguin Books.

 

2. Darwin, C. 1871. The descent of man and selection in relation to sex. London, Murray.

 

3. Darwin’s sexual selection theory – a forgotten idea

4. Paulo Gama Mota Departamento de Ciências da Vida Universidade de Coimbra, Portugal. https://www.uc.pt/en/cia/publica/AP_artigos/AP26.27.10_paulomota

 

6. Influence of HLA on human partnership and sexual satisfaction J. Kromer1, T. Hummel1, D. Pietrowski1, A. S.Giani2, J. Sauter2, G. Ehninger3, A. H. Schmidt2 & I. Croy1,4 https://cyberleninka.org/article/n/676372.pdf

 

7. Male steroid hormones and female preference for male body odor, Markus J. 8 Rantalaa,*,1, C.J. Peter Erikssonb , Anssi Vainikkaa , Raine Korteta,2 a Department of 9 Biological and Environmental Science, University of Jyva¨skyla¨, P.O. Box 35, FIN-40014 10 Jyva¨skyla¨, Finland b Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.391.8996&rep=rep1&type=pdf

Dr Mokhamed Orabi
Dr Mokhamed Orabi
Dr Mokhamed Orabi is an experienced specialty doctor in the Obstetric and Gynecology Department at St Mary’s Hospital, Isle of Wight Trust. He is a member of the Royal College of Obstetricians and the Royal College of Obstetricians Gynecologists MRCOG London and has Diplomate in Obstetrics & Gynecology from College of medicine of South Africa ( Dip Obst SA) CMSA; Clinical Ordinatura O&G (MD) - M Gorky Donetsk State University and a MBChB from Baghdad University. His Special interest are feto-maternal medicine ,colposcopy and medical education.
Dr Mokhamed Orabi
Dr Mokhamed Orabi
Dr Mokhamed Orabi
Dr Mokhamed Orabi is an experienced specialty doctor in the Obstetric and Gynecology Department at St Mary’s Hospital, Isle of Wight Trust. He is a member of the Royal College of Obstetricians and the Royal College of Obstetricians Gynecologists MRCOG London and has Diplomate in Obstetrics & Gynecology from College of medicine of South Africa ( Dip Obst SA) CMSA; Clinical Ordinatura O&G (MD) - M Gorky Donetsk State University and a MBChB from Baghdad University. His Special interest are feto-maternal medicine ,colposcopy and medical education.

Undiagnosed live term extra-uterine abdominal pregnancy

Introduction Abdominal pregnancy usually presents with signs and symptoms before the pregnancy reaches an advanced stage. They pose a high-risk to the mother and the baby, mainly due to the risk of bleeding and poor placental implantation respectively. Case overview I present a case of advanced abdominal pregnancy. The pregnancy reached 40+5/40 without any signs or symptoms and with a

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1. Atrash, H.K., A. Friede, and C.J. Hogue, Abdominal pregnancy in the United States: frequency and maternal
mortality. Obstet Gynecol, 1987. 69(3 Pt 1): p. 333-7.

2. Authors:, M. Thomas A Molinaro, and M. Kurt T Barnhart, MSCE, Abdominal pregnancy, cesarean scar pregnancy, and heterotopic pregnancy. 2018.

3. Baffoe, P., C. Fofie, and B.N. Gandau, Term abdominal pregnancy with healthy newborn: a case report. Ghana medical journal, 2011. 45(2): p. 81-83.

4. Mengistu, Z., A. Getachew, and M. Adefris, Term abdominal pregnancy: a case report. Journal of medical case reports, 2015. 9: p. 168-168.

5. Zhang, J., F. Li, and Q. Sheng, Full-term abdominal pregnancy: a case report and review of the literature. Gynecologic and obstetric investigation, 2008. 65(2): p. 139-141.

6. Adesiyun, A.G. and A.I. Audu, Term extrauterine pregnancy in a Nigerian mother: a complication of uterine dehiscence. Archives of gynecology and obstetrics, 2009. 279(1): p. 75.

7. Buchmann, P.E., GUIDELINES FOR MATERNITY CARE IN SOUTH AFRICA. 2015.

8. Agarwal, N. and F. Odejinmi, Early abdominal ectopic pregnancy: challenges, update and review of current management. The Obstetrician & Gynaecologist, 2014. 16(3): p. 193-198.

9. Martin, J.N. and J.F. McCaul, EMERGENT MANAGEMENT OF ABDOMINAL PREGNANCY. Clinical Obstetrics and Gynecology, 1990. 33(3): p. 438-447.

10 Costa, S., J. Presley, and G. Bastert, Advanced abdominal pregnancy. Obstetrical & gynecological survey, 1991. 46(8): p. 515-525.

11 Sagili, H. and K. Mohamed, Pregnancy of unknown location: an evidence-based approach to management. The Obstetrician & Gynaecologist, 2008. 10(4): p. 224-230.

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Circulating tumour DNA gives treatment options for the most common ovarian cancer type

High-grade serous ovarian cancer (HGSOC) is the most common and aggressive subtype of ovarian cancer. The HGSOC tumours consist of several heterogeneous cell populations with a large number of mutations. This genetic variability makes it difficult to find drugs that would kill all the cancer cells, and to which the cells would not become resistant during treatment. Over half of the patients diagnosed with high-grade serous ovarian cancer die within five years of diagnosis, that is, annually more than 150 000 women globally.

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DNA test is an effective cervical cancer screening tool for women in low-income countries

Cervical cancer is a major issue in low- and middle-income countries due to the lack of adequate screening such as routine Pap smear testing. These countries have high incidences of cervical cancer linked to human papillomavirus (HPV). Due to lack of resources for cancer screenings, these countries account for 85 percent of all cervical cancer cases.

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Diet high in leucine may fuel breast cancer’s drug resistance

A team of researchers has discovered an unexpected relationship between levels of the amino acid leucine and the development of tamoxifen resistance in ER breast cancer.

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Cervical cancer is more aggressive when human papillomavirus is not detected

Cervical cancer negative for the human papilloma virus (HPV) is rare but more aggressive: it is more frequently diagnosed at advanced stages, with more metastasis and reduced survival. These conclusions are published in Modern Pathology. The study was co-led by ISGlobal, an institution supported by “la Caixa”, the Hospital Clinic and the University of Barcelona.

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Treatment of abnormal menstrual bleeding in adolescents

Dr Bedei, Dr Delisle, Dr Hofmann-Werther, and Dr Pour Mirza highlight how to treat abnormal menstrual bleeding in adolescents.

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Prenatal diagnosis of Turner syndrome

Dr Ivonne Bedei, Dr Amelie Hofmann-Werther, and Dr Afshin Pour Mirza provide detailed information about the prenatal diagnosis of Turner syndrome.

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  1. Jeon KC, Chen L-S. Decision to abort after a prenatal diagnosis of sex chromosome abnormality: a systematic review of the literature. Genet Med 2012:14(1):27-38)

2. Sävendahl L, Davenport ML. Delayed diagnosis of Turner´s syndrome: proposed guidelines for change. J Pediatr. 2000;137(4):455-459).

3. Dondorp W, de Wert G, Bombard Y, et al. Non-invasive prenatal testing for aneuploidy and beyond: challenges of responsible innovation in prenatal screening. Eur J Hum Genet. 2015;23:1438-1450.

4. Schmid M, Klaritsch P, Arzt W, Burkhardt T, Duba H, Häusler M, et al. Cell-free DNA testing for fetal chromosomal anomalies in clinical practice: Austrian-German-Swiss recommendations for non-invasive prenatal tests (NIPT). Ultraschall Med – Eur J Ultrasound 2015;36:507–10).

5. Murdock DR, Donovan FX, Chandrasekharappa SC, Banks N, Bondy C, Muenke M, et al. Whole-exome Sequencing for Diagnosis of Turner syndrome: Towards Next Generation Sequencing and Newborn Screening. J Clin Endocrinol Metab. 2017

6. Hook EB, Warburton D. The distribution of chromosomal genotypes associated with Turner´s syndrome: livebirth prevalence rates and evidence for diminished fetal mortality and severity in genotypes associated with structural X abnormalities or mosaicism. Hum Genet. 1983;64:24-7

7. Alpman A, Cogulu O, Akgul M, Arikan EA, Durmaz B, Karaca E, Sadol S, Ozkinay C, Ozkinay F 2009 Prenatally diagnosed Turner syndrome and cystic hygroma: incidence and reasons for referrals. Fetal Diagn Ther 25:58-61)

8. Bondy C. Recent Developments in Diagnosis and Care for girls with Turner syndrome. Advances in Endocrinology Volume 2014, Article ID 231089.

9. Ibarra-Ramirez M, Martinez-de-Villareal LE. Clinical and genetic aspects of Turner´s syndrome. Medicina Universitaria. 2016;18(70):42-48).

10. Viuff MH, Stochholm K, Uldbjerg N, Nielsen BB, the Danish Fetal Medicine Study Group, and Gravholt CH. Only a minority of sex chromosome abnormalities are detected by a national prenatal sceening program for Down syndrome.Human Reproduction, Vol.30, No 10pp.2419-2426,2015).

11. Sybert VP, McCauley E. Turner´s Syndrome N Engl J Med 2004; 351:1227-1238,

12. Chang HJ, Clark RD, Bachman H. The Phenotype of 45,X/46,XY Mosaicism: An Analysis of 92 Prenatally Diagnosed Cases. Am. J. Genet. 46:156-167, 1990).

13. Gil MM, Accurti V, Santacruz B, Plana MN, Nicolaides KH. Analysis of cell-free DNA in maternal blood in screening for aneuploidies: updated meta-analysis. Ultrasound Obstet Gynecol 2017; 50:302-314).

14. Reiss RE, Discenza M, Foster J, Dobson L, Wilkins-Haug L. Sex chromosome aneuploidy detection by noninvasive prenatal testing: helpful or hazardous? Prenatal Diagnosis 2017, 37; 515-520

15. Grati FR, Bajaj K, Zanalfa V, Malvestiti F, Malvestiti B, Marcato L. Implications of fetoplacental mosaicism on cell-free DNA testing for sex chromosome aneuploidies. Prenatal Diagnosis 2017. 37. 1017-1027).

16. Malvestiti F, Agrati C, Grimi B, et al. Interpreting mosaicism in chorionic vili: results of a monocentric series of 1001 mosaics in chorionic villi with follow-up amniocentesis. Prenatal Diagnosis 2015, 35, 1117-1127)

17. Russell LM, Strike P, Browne CE, Jacobs PA. X Chromosome loss and aging. Cytogenet Genome Res 116:181-185(2007).

18. Zhang B, Lu B-Y, Zheng F-X, Zhou Q, Cheng Y-P, Zhang X-Q. Noninvasive prenatal screening for fetal common sex chromosome aneuploidies from maternal blood. J Med Res. 2017 Apr; 45(2): 621-630.

19. Bevilacqua E, Ordonez E, Hurtado I, Rueda L, Mazzone E, Cirigliano V, Jani JC. Screening for Sex Chromosome Aneuploidy by Cell-Free DNA Testing: Patient Choice and Performance. Fetal Diagn Ther DOI: 10.1159/000479507.

20. Chitty LS, Hudgins L, Norton ME. Current controversies in prenatal diagnosis 2: Cell-free DNA prenatal screening should be used to identify all chromosome abnormalities. Prenatal Diagnosis. 2018;38:160-165)

21. Samango-Sprouse C, Banjevic M, Ryan A, Sigurjonsson S, Zimmermann B, Hill M, Hall MP, Westmeyer M, Saucier J, Demko Z, Rabinowitz M. SNP-based non-invasive prenatal testing detects sex chromosome aneuploidies with high accuracy. Prenat Diagn. 2013 July; 33(7): 643-649.

22. Bronstein M, Zimmer EZ & Blazer S. A characteristic cluster of fetal sonographic markers that are predictive of fetal Turner syndrome in early pregnancy. American Journal of Obstetrics and Gynecology 2003 188 1016-1020.

23. Gravholt CH et al. Clinical practice guideline for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner syndrome Meeting. European Journal of Endocrinology 2017;177:3 G1-G70).

Dr Hina Naveed
Dr Hina Naveed
Hina is the Marketing Manager at the Middle East Medical Portal. She is an experienced Pharmacist, writer, and speaker. Hina lives in the United Arab Emirates.
Dr Hina Naveed
Dr Hina Naveed
Dr Hina Naveed
Hina is the Marketing Manager at the Middle East Medical Portal. She is an experienced Pharmacist, writer, and speaker. Hina lives in the United Arab Emirates.

Thyroid and infertility in women

According to a Harvard Medical School study, having even a slightly underactive thyroid may interfere with a woman’s ability to get pregnant. Dr Hina Naveed provides further information about thyroid diseases and fertility.

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Dr Dhananjay Sanjekar
Dr Dhananjay Sanjekar
MBBS, MD [Mumbai Unv.]; Diploma in Anaesthetics from College of Physicians and Surgeons of Mumbai; Diplomate of National Board, New Delhi; Dip. Healthcare management, UK; Certified Professional, Healthcare quality, USA; Ex.Trust Doctor, NHS, UK; Specialist Anaesthsiologist, Zulekha Hospital, Dubai, UAE
Dr Dhananjay Sanjekar
Dr Dhananjay Sanjekar
Dr Dhananjay Sanjekar
MBBS, MD [Mumbai Unv.]; Diploma in Anaesthetics from College of Physicians and Surgeons of Mumbai; Diplomate of National Board, New Delhi; Dip. Healthcare management, UK; Certified Professional, Healthcare quality, USA; Ex.Trust Doctor, NHS, UK; Specialist Anaesthsiologist, Zulekha Hospital, Dubai, UAE

Labour analgesia options and labour-related complications

Dr Dhanajay discusses pain in childbirth and highlights where labour is in correlation to the McGill pain index. Furthermore, labour-related complications and maternal mortality in the MENA region.

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View references

  1. Dr Matt Rucklidge, “Anaesthesia UK : Analgesia for labour,” URL http://www.frca.co.uk/article.aspx?articleid=100551

2. Indian J Anaesth. 2010 Sep-Oct; 54(5): 400–408. doi:  10.4103/0019-5049.71033

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