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Treatment of abnormal menstrual bleeding in adolescents

Dr Bedei, Dr Delisle, Dr Hofmann-Werther, and Dr Pour Mirza highlight how to treat abnormal menstrual bleeding in adolescents.

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Prenatal diagnosis of Turner syndrome

Dr Ivonne Bedei, Dr Amelie Hofmann-Werther, and Dr Afshin Pour Mirza provide detailed information about the prenatal diagnosis of Turner syndrome.

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View references

  1. Jeon KC, Chen L-S. Decision to abort after a prenatal diagnosis of sex chromosome abnormality: a systematic review of the literature. Genet Med 2012:14(1):27-38)

2. Sävendahl L, Davenport ML. Delayed diagnosis of Turner´s syndrome: proposed guidelines for change. J Pediatr. 2000;137(4):455-459).

3. Dondorp W, de Wert G, Bombard Y, et al. Non-invasive prenatal testing for aneuploidy and beyond: challenges of responsible innovation in prenatal screening. Eur J Hum Genet. 2015;23:1438-1450.

4. Schmid M, Klaritsch P, Arzt W, Burkhardt T, Duba H, Häusler M, et al. Cell-free DNA testing for fetal chromosomal anomalies in clinical practice: Austrian-German-Swiss recommendations for non-invasive prenatal tests (NIPT). Ultraschall Med – Eur J Ultrasound 2015;36:507–10).

5. Murdock DR, Donovan FX, Chandrasekharappa SC, Banks N, Bondy C, Muenke M, et al. Whole-exome Sequencing for Diagnosis of Turner syndrome: Towards Next Generation Sequencing and Newborn Screening. J Clin Endocrinol Metab. 2017

6. Hook EB, Warburton D. The distribution of chromosomal genotypes associated with Turner´s syndrome: livebirth prevalence rates and evidence for diminished fetal mortality and severity in genotypes associated with structural X abnormalities or mosaicism. Hum Genet. 1983;64:24-7

7. Alpman A, Cogulu O, Akgul M, Arikan EA, Durmaz B, Karaca E, Sadol S, Ozkinay C, Ozkinay F 2009 Prenatally diagnosed Turner syndrome and cystic hygroma: incidence and reasons for referrals. Fetal Diagn Ther 25:58-61)

8. Bondy C. Recent Developments in Diagnosis and Care for girls with Turner syndrome. Advances in Endocrinology Volume 2014, Article ID 231089.

9. Ibarra-Ramirez M, Martinez-de-Villareal LE. Clinical and genetic aspects of Turner´s syndrome. Medicina Universitaria. 2016;18(70):42-48).

10. Viuff MH, Stochholm K, Uldbjerg N, Nielsen BB, the Danish Fetal Medicine Study Group, and Gravholt CH. Only a minority of sex chromosome abnormalities are detected by a national prenatal sceening program for Down syndrome.Human Reproduction, Vol.30, No 10pp.2419-2426,2015).

11. Sybert VP, McCauley E. Turner´s Syndrome N Engl J Med 2004; 351:1227-1238,

12. Chang HJ, Clark RD, Bachman H. The Phenotype of 45,X/46,XY Mosaicism: An Analysis of 92 Prenatally Diagnosed Cases. Am. J. Genet. 46:156-167, 1990).

13. Gil MM, Accurti V, Santacruz B, Plana MN, Nicolaides KH. Analysis of cell-free DNA in maternal blood in screening for aneuploidies: updated meta-analysis. Ultrasound Obstet Gynecol 2017; 50:302-314).

14. Reiss RE, Discenza M, Foster J, Dobson L, Wilkins-Haug L. Sex chromosome aneuploidy detection by noninvasive prenatal testing: helpful or hazardous? Prenatal Diagnosis 2017, 37; 515-520

15. Grati FR, Bajaj K, Zanalfa V, Malvestiti F, Malvestiti B, Marcato L. Implications of fetoplacental mosaicism on cell-free DNA testing for sex chromosome aneuploidies. Prenatal Diagnosis 2017. 37. 1017-1027).

16. Malvestiti F, Agrati C, Grimi B, et al. Interpreting mosaicism in chorionic vili: results of a monocentric series of 1001 mosaics in chorionic villi with follow-up amniocentesis. Prenatal Diagnosis 2015, 35, 1117-1127)

17. Russell LM, Strike P, Browne CE, Jacobs PA. X Chromosome loss and aging. Cytogenet Genome Res 116:181-185(2007).

18. Zhang B, Lu B-Y, Zheng F-X, Zhou Q, Cheng Y-P, Zhang X-Q. Noninvasive prenatal screening for fetal common sex chromosome aneuploidies from maternal blood. J Med Res. 2017 Apr; 45(2): 621-630.

19. Bevilacqua E, Ordonez E, Hurtado I, Rueda L, Mazzone E, Cirigliano V, Jani JC. Screening for Sex Chromosome Aneuploidy by Cell-Free DNA Testing: Patient Choice and Performance. Fetal Diagn Ther DOI: 10.1159/000479507.

20. Chitty LS, Hudgins L, Norton ME. Current controversies in prenatal diagnosis 2: Cell-free DNA prenatal screening should be used to identify all chromosome abnormalities. Prenatal Diagnosis. 2018;38:160-165)

21. Samango-Sprouse C, Banjevic M, Ryan A, Sigurjonsson S, Zimmermann B, Hill M, Hall MP, Westmeyer M, Saucier J, Demko Z, Rabinowitz M. SNP-based non-invasive prenatal testing detects sex chromosome aneuploidies with high accuracy. Prenat Diagn. 2013 July; 33(7): 643-649.

22. Bronstein M, Zimmer EZ & Blazer S. A characteristic cluster of fetal sonographic markers that are predictive of fetal Turner syndrome in early pregnancy. American Journal of Obstetrics and Gynecology 2003 188 1016-1020.

23. Gravholt CH et al. Clinical practice guideline for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner syndrome Meeting. European Journal of Endocrinology 2017;177:3 G1-G70).

Dr Hina Naveed
Hina is the Marketing Manager at the Middle East Medical Portal. She is an experienced Pharmacist, writer, and speaker. Hina lives in the United Arab Emirates.
Dr Hina Naveed
Dr Hina Naveed
Dr Hina Naveed
Hina is the Marketing Manager at the Middle East Medical Portal. She is an experienced Pharmacist, writer, and speaker. Hina lives in the United Arab Emirates.

Thyroid and infertility in women

According to a Harvard Medical School study, having even a slightly underactive thyroid may interfere with a woman’s ability to get pregnant. Dr Hina Naveed provides further information about thyroid diseases and fertility.

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Dr Dhananjay Sanjekar
MBBS, MD [Mumbai Unv.]; Diploma in Anaesthetics from College of Physicians and Surgeons of Mumbai; Diplomate of National Board, New Delhi; Dip. Healthcare management, UK; Certified Professional, Healthcare quality, USA; Ex.Trust Doctor, NHS, UK; Specialist Anaesthsiologist, Zulekha Hospital, Dubai, UAE
Dr Dhananjay Sanjekar
Dr Dhananjay Sanjekar
Dr Dhananjay Sanjekar
MBBS, MD [Mumbai Unv.]; Diploma in Anaesthetics from College of Physicians and Surgeons of Mumbai; Diplomate of National Board, New Delhi; Dip. Healthcare management, UK; Certified Professional, Healthcare quality, USA; Ex.Trust Doctor, NHS, UK; Specialist Anaesthsiologist, Zulekha Hospital, Dubai, UAE

Labour analgesia options and labour-related complications

Dr Dhanajay discusses pain in childbirth and highlights where labour is in correlation to the McGill pain index. Furthermore, labour-related complications and maternal mortality in the MENA region.

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View references

  1. Dr Matt Rucklidge, “Anaesthesia UK : Analgesia for labour,” URL http://www.frca.co.uk/article.aspx?articleid=100551

2. Indian J Anaesth. 2010 Sep-Oct; 54(5): 400–408. doi:  10.4103/0019-5049.71033

Dr Khaled Mohamed Aly
Dr Khaled Mohamed Aly is a medical specialist MBBCH; M.S.C Cairo University; ACLS -EP; ATLS-SL (South Africa) Critical care course program-USA Disastrous medicine; STEMI-certificate AHA Hospital management and infection control diplomas Cairo University. Author of Critical Care Professional Handbook. Dr Khalad is Head of CME in Egypt for MEMP Ltd.
Dr Khaled Mohamed Aly
Dr Khaled Mohamed Aly
Dr Khaled Mohamed Aly
Dr Khaled Mohamed Aly is a medical specialist MBBCH; M.S.C Cairo University; ACLS -EP; ATLS-SL (South Africa) Critical care course program-USA Disastrous medicine; STEMI-certificate AHA Hospital management and infection control diplomas Cairo University. Author of Critical Care Professional Handbook. Dr Khalad is Head of CME in Egypt for MEMP Ltd.

An insight on critical care in obstetrics

Pregnancy-related complications constitute a significant part in critical care, in this article Dr Khaled provides an insight on critical care in obstetrics. He highlights that the most common indications for ICU admission are postpartum hemorrhage, pregnancy induced hypertension, and related disorders.

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View references

1-Pollock W, Rose L, Dennis CL. Pregnant and postpartum admissions to the intensive care unit: a systematic review. Intensive Care Med 2010; 36:1465.

2-Chesnett AN. Physiology of normal pregnancy. Crit Care Clin. 2004;20:609615.

3-Lapinsky SE, Kruczynski K, Slutsky AS. Critical care in the pregnant patient. Am J Respir Crit Care Med. 1995;152:427-455.

4-Callaghan WM. Overview of maternal mortality in the United States. Semin Perinatol 2012; 36:2.

5-Chantry AA, Deneux-Tharaux C, Bonnet MP, Bouvier-Colle MH. Pregnancyrelated ICU admissions in France: trends in rate and severity, 2006-2009. Crit Care Med 2015; 43:78.

6-American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins—Obstetrics. Practice Bulletin No. 170: Critical Care in Pregnancy. Obstet Gynecol 2016; 128:e147. Reaffirmed 2017.

7-Committee on Obstetric Practice. Committee Opinion No. 692: Emergent Therapy for Acute-Onset, Severe Hypertension During Pregnancy and the Postpartum Period. Obstet Gynecol 2017; 129:e90.

8-Vasquez DN, Das Neves AV, Vidal L, et al. Characteristics, Outcomes, and Predictability of Critically Ill Obstetric Patients: A Multicenter Prospective Cohort Study. Crit Care Med 2015; 43:1887.

9-Regitz-Zagrosek V, Roos-Hesselink JW, Bauersachs J, et al. 2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy. Eur Heart J 2018; 39:3165.

Dr Amelie Hofmann-Werther
Dr Hofmann-Werther is a Specialist Gynaecology and Obstetrics, Fetal Medicine Sonographer, Psychosomatics and Verbal Intervention Counselor, colposcopist, CBD surgeon, Conference Organization Team, Scientific Committee and Advisory Board Member OBFEGYN.
Dr Amelie Hofmann-Werther
Dr Amelie Hofmann-Werther
Dr Amelie Hofmann-Werther
Dr Hofmann-Werther is a Specialist Gynaecology and Obstetrics, Fetal Medicine Sonographer, Psychosomatics and Verbal Intervention Counselor, colposcopist, CBD surgeon, Conference Organization Team, Scientific Committee and Advisory Board Member OBFEGYN.

Polycystic Ovarian Syndrome (PCOS): A lifestyle-related Problem?

Renowned gynecologist Dr Amelie Hofmann-Werther discusses whether Polycystic Ovarian Syndrome (PCOS) is A lifestyle-related Problem.

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View references

[1] Is the UAE making you infertile? | GulfNews.com

[2] Dr Salem El Shawarby, Consultant & UK Subspecialist in Reproductive Medicine/ IVF, Director of Corniche Fertility Centre, Corniche Hospital, Abu Dhabi, UAE, fridaymagazine.ae

[3] The prevalence of polycystic ovary syndrome in reproductive-aged women of different ethnicity: a systematic review and meta-analysis transform ncbi.nlm.nih.gov

Dr Amelie Hofmann-Werther
Dr Hofmann-Werther is a Specialist Gynaecology and Obstetrics, Fetal Medicine Sonographer, Psychosomatics and Verbal Intervention Counselor, colposcopist, CBD surgeon, Conference Organization Team, Scientific Committee and Advisory Board Member OBFEGYN.
Dr Amelie Hofmann-Werther
Dr Amelie Hofmann-Werther
Dr Amelie Hofmann-Werther
Dr Hofmann-Werther is a Specialist Gynaecology and Obstetrics, Fetal Medicine Sonographer, Psychosomatics and Verbal Intervention Counselor, colposcopist, CBD surgeon, Conference Organization Team, Scientific Committee and Advisory Board Member OBFEGYN.

Chronic pelvic pain and endometriosis

Renowned gynecologist Dr Amelie Hofmann-Werther explains the causes, symptoms, and treatments of chronic pelvic pain and endometriosis.

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Dr Hina Naveed
Hina is the Marketing Manager at the Middle East Medical Portal. She is an experienced Pharmacist, writer, and speaker. Hina lives in the United Arab Emirates.
Dr Hina Naveed
Dr Hina Naveed
Dr Hina Naveed
Hina is the Marketing Manager at the Middle East Medical Portal. She is an experienced Pharmacist, writer, and speaker. Hina lives in the United Arab Emirates.

An introduction to women’s health in the Middle East

An overview of female health issues in the Middle East, including reproductive illnesses, diabetes, and women’s nutritional needs.

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