General Medicine

Mecial Events

Contact us to enquire about advertising your events.

Editor
Editor
Editor
Editor

Prenatal diagnosis of Turner syndrome

Dr Ivonne Bedei, Dr Amelie Hofmann-Werther, and Dr Afshin Pour Mirza provide detailed information about the prenatal diagnosis of Turner syndrome.

Continue reading

View references

  1. Jeon KC, Chen L-S. Decision to abort after a prenatal diagnosis of sex chromosome abnormality: a systematic review of the literature. Genet Med 2012:14(1):27-38)

2. Sävendahl L, Davenport ML. Delayed diagnosis of Turner´s syndrome: proposed guidelines for change. J Pediatr. 2000;137(4):455-459).

3. Dondorp W, de Wert G, Bombard Y, et al. Non-invasive prenatal testing for aneuploidy and beyond: challenges of responsible innovation in prenatal screening. Eur J Hum Genet. 2015;23:1438-1450.

4. Schmid M, Klaritsch P, Arzt W, Burkhardt T, Duba H, Häusler M, et al. Cell-free DNA testing for fetal chromosomal anomalies in clinical practice: Austrian-German-Swiss recommendations for non-invasive prenatal tests (NIPT). Ultraschall Med – Eur J Ultrasound 2015;36:507–10).

5. Murdock DR, Donovan FX, Chandrasekharappa SC, Banks N, Bondy C, Muenke M, et al. Whole-exome Sequencing for Diagnosis of Turner syndrome: Towards Next Generation Sequencing and Newborn Screening. J Clin Endocrinol Metab. 2017

6. Hook EB, Warburton D. The distribution of chromosomal genotypes associated with Turner´s syndrome: livebirth prevalence rates and evidence for diminished fetal mortality and severity in genotypes associated with structural X abnormalities or mosaicism. Hum Genet. 1983;64:24-7

7. Alpman A, Cogulu O, Akgul M, Arikan EA, Durmaz B, Karaca E, Sadol S, Ozkinay C, Ozkinay F 2009 Prenatally diagnosed Turner syndrome and cystic hygroma: incidence and reasons for referrals. Fetal Diagn Ther 25:58-61)

8. Bondy C. Recent Developments in Diagnosis and Care for girls with Turner syndrome. Advances in Endocrinology Volume 2014, Article ID 231089.

9. Ibarra-Ramirez M, Martinez-de-Villareal LE. Clinical and genetic aspects of Turner´s syndrome. Medicina Universitaria. 2016;18(70):42-48).

10. Viuff MH, Stochholm K, Uldbjerg N, Nielsen BB, the Danish Fetal Medicine Study Group, and Gravholt CH. Only a minority of sex chromosome abnormalities are detected by a national prenatal sceening program for Down syndrome.Human Reproduction, Vol.30, No 10pp.2419-2426,2015).

11. Sybert VP, McCauley E. Turner´s Syndrome N Engl J Med 2004; 351:1227-1238,

12. Chang HJ, Clark RD, Bachman H. The Phenotype of 45,X/46,XY Mosaicism: An Analysis of 92 Prenatally Diagnosed Cases. Am. J. Genet. 46:156-167, 1990).

13. Gil MM, Accurti V, Santacruz B, Plana MN, Nicolaides KH. Analysis of cell-free DNA in maternal blood in screening for aneuploidies: updated meta-analysis. Ultrasound Obstet Gynecol 2017; 50:302-314).

14. Reiss RE, Discenza M, Foster J, Dobson L, Wilkins-Haug L. Sex chromosome aneuploidy detection by noninvasive prenatal testing: helpful or hazardous? Prenatal Diagnosis 2017, 37; 515-520

15. Grati FR, Bajaj K, Zanalfa V, Malvestiti F, Malvestiti B, Marcato L. Implications of fetoplacental mosaicism on cell-free DNA testing for sex chromosome aneuploidies. Prenatal Diagnosis 2017. 37. 1017-1027).

16. Malvestiti F, Agrati C, Grimi B, et al. Interpreting mosaicism in chorionic vili: results of a monocentric series of 1001 mosaics in chorionic villi with follow-up amniocentesis. Prenatal Diagnosis 2015, 35, 1117-1127)

17. Russell LM, Strike P, Browne CE, Jacobs PA. X Chromosome loss and aging. Cytogenet Genome Res 116:181-185(2007).

18. Zhang B, Lu B-Y, Zheng F-X, Zhou Q, Cheng Y-P, Zhang X-Q. Noninvasive prenatal screening for fetal common sex chromosome aneuploidies from maternal blood. J Med Res. 2017 Apr; 45(2): 621-630.

19. Bevilacqua E, Ordonez E, Hurtado I, Rueda L, Mazzone E, Cirigliano V, Jani JC. Screening for Sex Chromosome Aneuploidy by Cell-Free DNA Testing: Patient Choice and Performance. Fetal Diagn Ther DOI: 10.1159/000479507.

20. Chitty LS, Hudgins L, Norton ME. Current controversies in prenatal diagnosis 2: Cell-free DNA prenatal screening should be used to identify all chromosome abnormalities. Prenatal Diagnosis. 2018;38:160-165)

21. Samango-Sprouse C, Banjevic M, Ryan A, Sigurjonsson S, Zimmermann B, Hill M, Hall MP, Westmeyer M, Saucier J, Demko Z, Rabinowitz M. SNP-based non-invasive prenatal testing detects sex chromosome aneuploidies with high accuracy. Prenat Diagn. 2013 July; 33(7): 643-649.

22. Bronstein M, Zimmer EZ & Blazer S. A characteristic cluster of fetal sonographic markers that are predictive of fetal Turner syndrome in early pregnancy. American Journal of Obstetrics and Gynecology 2003 188 1016-1020.

23. Gravholt CH et al. Clinical practice guideline for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner syndrome Meeting. European Journal of Endocrinology 2017;177:3 G1-G70).

Dr Hina Naveed
Hina is the Marketing Manager at the Middle East Medical Portal. She is an experienced Pharmacist, writer, and speaker. Hina lives in the United Arab Emirates.
Dr Hina Naveed
Dr Hina Naveed
Dr Hina Naveed
Hina is the Marketing Manager at the Middle East Medical Portal. She is an experienced Pharmacist, writer, and speaker. Hina lives in the United Arab Emirates.

Thyroid and infertility in women

According to a Harvard Medical School study, having even a slightly underactive thyroid may interfere with a woman’s ability to get pregnant. Dr Hina Naveed provides further information about thyroid diseases and fertility.

Continue reading
Dr Hoda Yousry, MD, PhD, DHPE
Dr Hoda is a Lecturer of Medical Genetics; Director of Information & Technology Unit, FOMSCU; Training Coordinator, CEMCM and the Founder & Entrepreneur at MED PREDICT Inc. She has received many awards for her work including Scientific Excellence awards and Best Scientific Research Awards at the Faculty of Medicine, Suez Canal University.
Dr Hoda Yousry, MD, PhD, DHPE
Dr Hoda Yousry, MD, PhD, DHPE
Dr Hoda Yousry, MD, PhD, DHPE
Dr Hoda is a Lecturer of Medical Genetics; Director of Information & Technology Unit, FOMSCU; Training Coordinator, CEMCM and the Founder & Entrepreneur at MED PREDICT Inc. She has received many awards for her work including Scientific Excellence awards and Best Scientific Research Awards at the Faculty of Medicine, Suez Canal University.

LifeTime initiative for revolutionizing global health care

Dr Hoda, attended the 2018 Falling Walls international conference on future breakthroughs in science and society in Berlin, Germany. Along with other 20 eminent participants from various backgrounds and expertise; she was invited to discuss the LifeTime initiative vision from different angles.

Continue reading
Ahmed Salem
Ahmed is currently studying Biotechnology at Faculty of Science, Mansoura University. He's a Researcher, Youtuber, and Writer. Ahmed is the youngest member of a team which aim to create the first molecular Map for Spinal Cord Injury which is a joint project between Mansoura University and LCSB - Luxembourg Centre for Systems Biomedicine, University of Luxembourg.
Ahmed Salem
Ahmed Salem
Ahmed Salem
Ahmed is currently studying Biotechnology at Faculty of Science, Mansoura University. He's a Researcher, Youtuber, and Writer. Ahmed is the youngest member of a team which aim to create the first molecular Map for Spinal Cord Injury which is a joint project between Mansoura University and LCSB - Luxembourg Centre for Systems Biomedicine, University of Luxembourg.

An overview of chromosomal aberrations

Ahmed Salem provides an overview of chromosome aberrations, including: Down syndrome, Edwards syndrome, Turner syndrome (xo) syndrome, Klinefelter syndrome, Triple X syndrome, Williams syndrome, 22q11.2 deletion syndrome, and Tetraploidy.

Continue reading

View references

  1. Center for Arab Genomic Studies Cags.org.ae. (2019). [online] Available at: http://www.cags.org.ae/Down%20Syndrome-English.pdf 

2. NDSS. (2019). What is Down Syndrome? | National Down Syndrome Society. [online] Available at: https://www.ndss.org/about-down-syndrome/down-syndrome/

3.  nhs.uk. (2019). Patau’s syndrome. [online] Available at: https://www.nhs.uk/conditions/pataus-syndrome/

4.Trisomy 13. [online] Genetics Home Reference. Available at: https://ghr.nlm.nih.gov/condition/trisomy-13#genes

5. Genetics Home Reference. Available at: https://ghr.nlm.nih.gov/condition/trisomy-18#statistics

6. Genetics Home Reference. Available at: https://ghr.nlm.nih.gov/condition/turner-syndrome

7.Genetics Home Reference. Available at: https://ghr.nlm.nih.gov/condition/klinefelter-syndrome#genes

8. Genetics Home Reference. Available at: https://ghr.nlm.nih.gov/condition/triple-x-syndrome

9. Genetics Home Reference. Available at: https://ghr.nlm.nih.gov/condition/williams-syndrome

10. Genetics Home Reference. Available at: https://ghr.nlm.nih.gov/condition/22q112-deletion-syndrome#genes

11. https://rarediseases.info.nih.gov/diseases/5151/tetraploidy

Brian de Francesca
Brian is an international expert in the use of digitalization and connectivity to improve all aspects of healthcare. He speaks and writes regularly on a wide range of topics including: telemedicine, artificial intelligence, quantum computing, bio-sensors, and many more interrelated and innovative digital topics that are changing the face of medicine world-wide.
Brian de Francesca
Brian de Francesca
Brian de Francesca
Brian is an international expert in the use of digitalization and connectivity to improve all aspects of healthcare. He speaks and writes regularly on a wide range of topics including: telemedicine, artificial intelligence, quantum computing, bio-sensors, and many more interrelated and innovative digital topics that are changing the face of medicine world-wide.

“The greatest humanitarian aid initiative in history”

Whilst volunteering in a refugee camp, Brian de Francesca’s mission became clear; to use telemedicine, AI, and blockchain to help 65 million global refugees.

Continue reading
Editor
Editor
Editor
Editor

Conversion of breast cancer cells into fat cells impedes the formation of metastases

An innovative combination therapy can force malignant breast cancer cells to turn into fat cells. This can be used to prevent the formation of metastases in mice, as researchers at the University of Basel’s Department of Biomedicine recently reported

Continue reading
Dr Khaled Mohamed Aly
Dr Khaled Mohamed Aly is a medical specialist MBBCH; M.S.C Cairo University; ACLS -EP; ATLS-SL (South Africa) Critical care course program-USA Disastrous medicine; STEMI-certificate AHA Hospital management and infection control diplomas Cairo University. Author of Critical Care Professional Handbook. Dr Khalad is Head of CME in Egypt for MEMP Ltd.
Dr Khaled Mohamed Aly
Dr Khaled Mohamed Aly
Dr Khaled Mohamed Aly
Dr Khaled Mohamed Aly is a medical specialist MBBCH; M.S.C Cairo University; ACLS -EP; ATLS-SL (South Africa) Critical care course program-USA Disastrous medicine; STEMI-certificate AHA Hospital management and infection control diplomas Cairo University. Author of Critical Care Professional Handbook. Dr Khalad is Head of CME in Egypt for MEMP Ltd.

Life-threatening complications of diabetes

he management of severe hypoglycemia and hyperglycemia in relation to the life-threatening complications of diabetes by Dr Khaled Mohammed Aly.

Continue reading

View references

  1. Inzucchi SE, Bergenstal RM, Buse JB, et al; American Diabetes Association (ADA); European Association for the Study of Diabetes (EASD). Management of hyperglycemia in type 2 diabetes: a patient-centered approach. Diabetes Care. 2012;35(6):1364-1369.

2. [Guideline] American Diabetes Association Professional Practice Committee. American Diabetes Association clinical practice recommendations: 2013. Diabetes Care. January 2013. 36 (suppl 1):S1-S110.

3. Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care. 2003 Jan. 26 Suppl 1:S5-20.

4. Stern MP. Do non-insulin-dependent diabetes mellitus and cardiovascular disease share common antecedents?. Ann Intern Med. 1996 Jan 1. 124(1 Pt 2):110-6.

5. Haffner SM, D’Agostino R Jr, Mykkanen L, Tracy R, Howard B, Rewers M, et al. Insulin sensitivity in subjects with type 2 diabetes. Relationship to cardiovascular risk factors: the Insulin Resistance Atherosclerosis Study. Diabetes Care. 1999 Apr. 22(4):562-8.

6. Rodbard HW, Jellinger PS, Davidson JA, Einhorn D, Garber AJ, Grunberger G, et al. Statement by an American Association of Clinical Endocrinologists/American College of Endocrinology consensus panel on type 2 diabetes mellitus: an algorithm for glycemic control. Endocr Pract. 2009 Sep-Oct. 15(6):540-59

7. Sacks DB, Arnold M, Bakris GL, Bruns DE, Horvath AR, Kirkman MS, et al. Executive summary: guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Clin Chem. 2011 Jun. 57(6):793-8.

8. Gerstein HC, Miller ME, Genuth S, Ismail-Beigi F, Buse JB, Goff DC Jr, et al. Long-term effects of intensive glucose lowering on cardiovascular outcomes. N Engl J Med. 2011 Mar 3. 364(9):81828.

9. Diabetes Advocacy: Standards of Medical Care in Diabetes-2018. Diabetes Care. 2018 Jan. 41 (Suppl 1):S152-3

10. Weiss JS, Sumpio BE (February 2006). “Review of prevalence and outcome of vascular disease in patients with diabetes mellitus”. European Journal of Vascular and Endovascular Surgery. 31 (2): 143–50

11. Granberg V, Ejskjaer N, Peakman M, Sundkvist G (August 2005). “Autoantibodies to autonomic nerves associated with cardiac and peripheral autonomic neuropathy”. Diabetes Care. 28 (8): 1959–64

12. Ichinose K, Kawasaki E, Eguchi K (2007). “Recent advancement of understanding pathogenesis of type 1 diabetes and potential relevance to diabetic nephropathy”. Am. J. Nephrol. 27 (6): 554– 64

Dr Dhananjay Sanjekar
MBBS, MD [Mumbai Unv.]; Diploma in Anaesthetics from College of Physicians and Surgeons of Mumbai; Diplomate of National Board, New Delhi; Dip. Healthcare management, UK; Certified Professional, Healthcare quality, USA; Ex.Trust Doctor, NHS, UK; Specialist Anaesthsiologist, Zulekha Hospital, Dubai, UAE
Dr Dhananjay Sanjekar
Dr Dhananjay Sanjekar
Dr Dhananjay Sanjekar
MBBS, MD [Mumbai Unv.]; Diploma in Anaesthetics from College of Physicians and Surgeons of Mumbai; Diplomate of National Board, New Delhi; Dip. Healthcare management, UK; Certified Professional, Healthcare quality, USA; Ex.Trust Doctor, NHS, UK; Specialist Anaesthsiologist, Zulekha Hospital, Dubai, UAE

Labour analgesia options and labour-related complications

Dr Dhanajay discusses pain in childbirth and highlights where labour is in correlation to the McGill pain index. Furthermore, labour-related complications and maternal mortality in the MENA region.

Continue reading

View references

  1. Dr Matt Rucklidge, “Anaesthesia UK : Analgesia for labour,” URL http://www.frca.co.uk/article.aspx?articleid=100551

2. Indian J Anaesth. 2010 Sep-Oct; 54(5): 400–408. doi:  10.4103/0019-5049.71033

Dr Marwan Elbagoury
Marwan is an Alexandria University, Pharmacy graduate (2006), MBA from Cambridge KIPP (2015), Bachelor of Law graduate (2018), M.Sc. of Advanced Oncology (2018). He has over ten years experience in multinational biotechnology companies and has twelve scientific papers published.
Dr Marwan Elbagoury
Dr Marwan Elbagoury
Dr Marwan Elbagoury
Marwan is an Alexandria University, Pharmacy graduate (2006), MBA from Cambridge KIPP (2015), Bachelor of Law graduate (2018), M.Sc. of Advanced Oncology (2018). He has over ten years experience in multinational biotechnology companies and has twelve scientific papers published.

Breast cancer risk-factors and benefits of early screening

Although breast cancer is the most common type of female cancer throughout the Middle East, many women do not seek medical care promptly. Consequently, the region has increased rates of late incidences. Dr Marwan Elbagouray explains breast cancer risks and the benefits of early screening.

Continue reading

View references

1. Parkin DM, Pisani P, Ferlay J. Global cancer statistics. CA Cancer J Clin. 1999;49(1):1,33-64. doi:10.3322/caac.20107.Available

2. New Horizons in Cancer Management, SRI International, 1990.

3. Feuer EJ, Wun LM, Boring CC, Flanders WD, Timmel MJ, Tong T. The lifetime risk of developing breast cancer. J Natl Cancer Inst. 1993;85(11):892-897.

4. Greenlee RT, Hill Harmon MB, Murray T, Thun M. Cancer Statistics, 2001. CA Cancer J Clin. 2001;51(1):15-36. doi:10.3322/canjclin.51.1.15

5. Henderson BE, Bernstein L, Ross RK. Breast Cancer. In: Kufe DW, Pollock RE, Weichselbaum RR, et al., editors. Holland-Frei Cancer Medicine. 6th edition. Hamilton (ON): BC Decker; 2003. Available from: https://www.ncbi.nlm.nih.gov/books/NBK13155/. https://gis.cdc.gov/Cancer/USCS/DataViz.html.

6. https://ww5.komen.org/WhatWeDo/AroundtheWorld/MiddleEast/MiddleEast.html.

7. Najjar H, Easson A. Age at diagnosis of breast cancer in Arab nations. Int J Surg. 2010;8(6):448-452. doi:10.1016/j.ijsu.2010.05.012

8. Dunn N, Cossio D, Blake M, Philpot S, Guan T, Theile DE. Asia-Pac JClinOncol2017;13:107–224. Mycoses. 2012;55(SUPPL.4):95-338. doi:10.1111/ajco.12799

9. Osteen RT. American Cancer Society Textbook of Clinical Oncology. 3rd ed. 2001;251-268.

10. Winer EP, et al. Cancer: Principles & Practice of Oncology. 6th ed. 2001;1651-1717.

11. Alberts DS. Fundamentals of Cancer Prevention.; 2014. doi:10.1007/978-3-642-38983-2

12. Tripathy D, Henderson IC. Current Cancer Therapeutics. 3rd ed. 1999;123-129.

13. Breast Surgical Techniques and Interdisciplinary Management. doi:https://doi.org/10.1007/978-1-4419-6076-4

14. http://teachmesurgery.com/examinations/misc/breast/.

15. http://www.fwhc.org/health/self-breast-exam.htm.

16. Bhandari A, Xia E, Wang Y, et al. Impact of sentinel lymph node biopsy in newly diagnosed invasive breast cancer patients with suspicious node: A comparative accuracy survey of fine-needle aspiration biopsy versus core-needle biopsy. Am J Transl Res. 2018;10(6):1860-1873.

17. Rimer BK, et al. Cancer: Principles & Practice of Oncology. 6th ed. 2001;627-640.

18. Smith RA. American Cancer Society Textbook of Clinical Oncology. 3rd ed. 2001:75-121.

19. Berg W a, Hendrick RE, Daniel B, Smith R a. Frequently Asked Questions about Mammography and the USPSTF Recommendations : A Guide for Practitioners. 2015;0:1-20.

20. Ciatto S, Cecchini S, Tossa A, Grazzini G, Bartoli D. Fine needle aspiration cytology and breast cancer diagnosis. Tumori. 1989;75(3):280-283. doi:10.1136/bmj.328.7430.1

21. Dollinger M, et al. Everyone’s Guide to Cancer Therapy. 1997;356-384.

22. AJCC® Cancer Staging Manual, 5th edition (1997) published by Lippincott-Raven Publishers, Philadelphia, Pennsylvania.

23. Csokay B, Udvarhelyi N, Olah E. Germline BRCA2 and somatic P53alterations in male breast cancer. Breast Cancer Res. 2000;2(S1):P1.12. doi:10.1186/bcr99

24. Slamon DJ. Chemotherapy Foundation Symposium. 1999;46. Abstract 39. Goldenberg MM. Clinical Therapeutics. 1999;21(2):309-318.

Dr Sora Al Rowas MD, MSc
Dr Sora Al Rowas is an internist who is passionate about general internal medicine and its role in medical education. She is also excited by underserved medicine and enjoys educating medical professionals on a range of topics.
Dr Sora Al Rowas MD, MSc
Dr Sora Al Rowas MD, MSc
Dr Sora Al Rowas MD, MSc
Dr Sora Al Rowas is an internist who is passionate about general internal medicine and its role in medical education. She is also excited by underserved medicine and enjoys educating medical professionals on a range of topics.

Common myths about mental health and why it should be a primary care issue

Dr Sora Al Rowas debunks some common mental health myths and she makes a strong case for why primary care providers need to take mental health seriously.

Continue reading

View references

[1] Dickens, Chris PhD; McGowan, Linda PhD; Dale, Steve MBBS; Impact of Depression on Experimental Pain Perception: A Systematic Review of the Literature with Meta-Analysis; Psychosomatic Medicine: May-June 2003 – Volume 65 – Issue 3 – p 369-375

Subscribe to our mailing list

 

 

Overlay