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Osama Atif
Osama Atif
Osama is a biotechnology undergraduate student at the Faculty of Science, Mansoura University and a student researcher at biotechnology field. He is interested in Medical Genetics and Molecular Pathology.
Osama Atif
Osama Atif
Osama Atif
Osama is a biotechnology undergraduate student at the Faculty of Science, Mansoura University and a student researcher at biotechnology field. He is interested in Medical Genetics and Molecular Pathology.

Disorder of thalassemias and hemoglobinopathies: A genetic overview

The thalassemia syndromes are genetic disorders characterized by absent or deficient synthesis of one or more of the normal globin chains. Biotechnologist Osama Atif provides an overview of these gentic disorders.

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View references

Cappellini MD. The thalassemias. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 162.

Chapin J, Giardina PJ. Thalassemia syndromes. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 40.

Weatherall, David J., and John B. Clegg. The thalassaemia syndromes. John Wiley & Sons, 2008.

Schrier, Stanley L. “Pathophysiology of thalassemia.” Current opinion in hematology 9.2 (2002): 123-126.

Chui DH, Waye JS. Hydrops fetalis caused by alpha-thalassemia: an emerging health care problem. Blood. 1998;91:2213–22.

Higgs DR, Bowden DK. Clinical and laboratory features of the alpha-thalassemia syndromes. In: Steinberg MH, Forget PG, Higgs DR, Nagel RL, eds. Disorders of Hemoglobin: Genetics, Pathophysiology, and Clinical Management. Cambridge, UK: Cambridge University Press; 2001:431-69.

Coelho A, Picanço I, Seuanes F, Seixas MT, Faustino P. Novel large deletions in the human alpha-globin gene cluster: Clarifying the HS-40 long-range regulatory role in the native chromosome environment. Blood Cells Mol Dis. 2010;45:147–53.

Chui DH: Alpha-thalassemia: Hb H disease and Hb Barts hydrops fetalis. Ann N Y Acad Sci. 2005, 1054: 25-32. 10.1196/annals.1345.004.

Ingram VM, Stretton AO: Genetic basis of the thalassaemia diseases. Nature. 1959, 184: 1903-1909. 10.1038/1841903a0.

Bernini L: Geographic distribution of alpha-thalassemia. Disorders of Hemoglobin. first edition. Edited by: Steinberg MH, Forget BG, Higgs DR, Nagel RL. Cambridge University Press; 2001:878-894.

Ko T, Hsieh FJ, Hsu PM, Lee TY. Molecular characterization of severe α-thalassemias causing hydrops fetalis in Taiwan. Am J Med Genet 1991; 39: 317–320.

Steensma DP, Viprakasit V, Hendrick A, Goff DK, Leach J, Gibbons RJ, Higgs DR. Deletion of the alpha-globin gene cluster as a cause of acquired alpha-thalassemia in myelodysplastic syndrome. Blood. 2004b;103:1518–20.

Galanello, Renzo, and Raffaella Origa. “Beta-thalassemia.” Orphanet journal of rare diseases 5.1 (2010): 11.

Weatherall DJ, Clegg JB. Inherited haemoglobin disorders: an increasing global health problem. Bull World Health Organ. 2001;79(8):704-712.

Weatherall DJ. Hemoglobinopathies worldwide: Present and future. Curr Mol Med. 2008;8:592–599

Steinberg MH, Forget BG, et al., editors. Disorders of hemoglobin: genetics, pathophysiology and clinical management. Cambridge University Press; 2001.

Verma S, Bhargava M, Mittal S, Gupta R. Homozygous delta-beta thalassemia in a child: a rare cause of elevated fetal hemoglobin. Iran J Ped Hematol Oncol. 2013;3:222–227.

Bollekens JA, Forget BG. Delta beta thalassemia and hereditary persistence of fetal hemoglobin. Hematol Oncol Clin North Am. 1991;5:399–422.

Forget, Bernard G. “Molecular basis of hereditary persistence of fetal hemoglobin.” Annals of the New York Academy of Sciences850.1 (1998): 38-44.

Bollekens, J. A. & B. G. Forget. 1991. δγ Thalassemia and hereditary persistence of fetal hemoglobin. Hematol. Oncol. Clin. North Am. 5: 399–422.

Dr Hoda Yousry, MD, PhD, DHPE
Dr Hoda Yousry, MD, PhD, DHPE
Dr Hoda is a Lecturer of Medical Genetics; Director of Information & Technology Unit, FOMSCU; Training Coordinator, CEMCM and the Founder & Entrepreneur at MED PREDICT Inc. She has received many awards for her work including Scientific Excellence awards and Best Scientific Research Awards at the Faculty of Medicine, Suez Canal University.
Dr Hoda Yousry, MD, PhD, DHPE
Dr Hoda Yousry, MD, PhD, DHPE
Dr Hoda Yousry, MD, PhD, DHPE
Dr Hoda is a Lecturer of Medical Genetics; Director of Information & Technology Unit, FOMSCU; Training Coordinator, CEMCM and the Founder & Entrepreneur at MED PREDICT Inc. She has received many awards for her work including Scientific Excellence awards and Best Scientific Research Awards at the Faculty of Medicine, Suez Canal University.

LifeTime initiative for revolutionizing global health care

Dr Hoda, attended the 2018 Falling Walls international conference on future breakthroughs in science and society in Berlin, Germany. Along with other 20 eminent participants from various backgrounds and expertise; she was invited to discuss the LifeTime initiative vision from different angles.

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Ahmed Salem
Ahmed Salem
Ahmed is currently studying Biotechnology at Faculty of Science, Mansoura University. He's a Researcher, Youtuber, and Writer. Ahmed is the youngest member of a team which aim to create the first molecular Map for Spinal Cord Injury which is a joint project between Mansoura University and LCSB - Luxembourg Centre for Systems Biomedicine, University of Luxembourg.
Ahmed Salem
Ahmed Salem
Ahmed Salem
Ahmed is currently studying Biotechnology at Faculty of Science, Mansoura University. He's a Researcher, Youtuber, and Writer. Ahmed is the youngest member of a team which aim to create the first molecular Map for Spinal Cord Injury which is a joint project between Mansoura University and LCSB - Luxembourg Centre for Systems Biomedicine, University of Luxembourg.

An overview of chromosomal aberrations

Ahmed Salem provides an overview of chromosome aberrations, including: Down syndrome, Edwards syndrome, Turner syndrome (xo) syndrome, Klinefelter syndrome, Triple X syndrome, Williams syndrome, 22q11.2 deletion syndrome, and Tetraploidy.

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View references

  1. Center for Arab Genomic Studies Cags.org.ae. (2019). [online] Available at: http://www.cags.org.ae/Down%20Syndrome-English.pdf 

2. NDSS. (2019). What is Down Syndrome? | National Down Syndrome Society. [online] Available at: https://www.ndss.org/about-down-syndrome/down-syndrome/

3.  nhs.uk. (2019). Patau’s syndrome. [online] Available at: https://www.nhs.uk/conditions/pataus-syndrome/

4.Trisomy 13. [online] Genetics Home Reference. Available at: https://ghr.nlm.nih.gov/condition/trisomy-13#genes

5. Genetics Home Reference. Available at: https://ghr.nlm.nih.gov/condition/trisomy-18#statistics

6. Genetics Home Reference. Available at: https://ghr.nlm.nih.gov/condition/turner-syndrome

7.Genetics Home Reference. Available at: https://ghr.nlm.nih.gov/condition/klinefelter-syndrome#genes

8. Genetics Home Reference. Available at: https://ghr.nlm.nih.gov/condition/triple-x-syndrome

9. Genetics Home Reference. Available at: https://ghr.nlm.nih.gov/condition/williams-syndrome

10. Genetics Home Reference. Available at: https://ghr.nlm.nih.gov/condition/22q112-deletion-syndrome#genes

11. https://rarediseases.info.nih.gov/diseases/5151/tetraploidy

H.E. Dr Maryam Matar, MD, PhD
H.E. Dr Maryam Matar, MD, PhD
Her Excellency, Dr Matar is the Founder and Chairperson, UAE Genetic Diseases Association. She is a leading healthcare influencer, and pioneered the study of genes and advocates public education and awareness of genetic disorders across the ME region. She serves as a Chairperson/senior advisor in over 15 international, regional and local committees for preventive healthcare initiatives, women in STEM, and youth leadership. Dr Mater has been recognised as the most powerful scientist in the UAE since 2014; amongst the top 20 Arab scientists with the biggest contribution to humanity by British Scientific Community 2016; amongst the “top 100 most influential Arabs in the world” recognised by Arabian Business for four consecutive years since 2013.
H.E. Dr Maryam Matar, MD, PhD
H.E. Dr Maryam Matar, MD, PhD
H.E. Dr Maryam Matar, MD, PhD
Her Excellency, Dr Matar is the Founder and Chairperson, UAE Genetic Diseases Association. She is a leading healthcare influencer, and pioneered the study of genes and advocates public education and awareness of genetic disorders across the ME region. She serves as a Chairperson/senior advisor in over 15 international, regional and local committees for preventive healthcare initiatives, women in STEM, and youth leadership. Dr Mater has been recognised as the most powerful scientist in the UAE since 2014; amongst the top 20 Arab scientists with the biggest contribution to humanity by British Scientific Community 2016; amongst the “top 100 most influential Arabs in the world” recognised by Arabian Business for four consecutive years since 2013.

Thalassemia: Facts you must Know

H.E. Dr Maryam Matar provides an overview of thalassemia and explains how the In the last ten years, UAE has made significant progress in preventive management and reduce the prevalence of the genetic disorder.

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H.E. Dr Maryam Matar, MD, PhD
H.E. Dr Maryam Matar, MD, PhD
Her Excellency, Dr Matar is the Founder and Chairperson, UAE Genetic Diseases Association. She is a leading healthcare influencer, and pioneered the study of genes and advocates public education and awareness of genetic disorders across the ME region. She serves as a Chairperson/senior advisor in over 15 international, regional and local committees for preventive healthcare initiatives, women in STEM, and youth leadership. Dr Mater has been recognised as the most powerful scientist in the UAE since 2014; amongst the top 20 Arab scientists with the biggest contribution to humanity by British Scientific Community 2016; amongst the “top 100 most influential Arabs in the world” recognised by Arabian Business for four consecutive years since 2013.
H.E. Dr Maryam Matar, MD, PhD
H.E. Dr Maryam Matar, MD, PhD
H.E. Dr Maryam Matar, MD, PhD
Her Excellency, Dr Matar is the Founder and Chairperson, UAE Genetic Diseases Association. She is a leading healthcare influencer, and pioneered the study of genes and advocates public education and awareness of genetic disorders across the ME region. She serves as a Chairperson/senior advisor in over 15 international, regional and local committees for preventive healthcare initiatives, women in STEM, and youth leadership. Dr Mater has been recognised as the most powerful scientist in the UAE since 2014; amongst the top 20 Arab scientists with the biggest contribution to humanity by British Scientific Community 2016; amongst the “top 100 most influential Arabs in the world” recognised by Arabian Business for four consecutive years since 2013.

Stem cell advancements may help treat ADHD

H.E. Dr Maryam Matar provides an overview of Attention Deficit Hyperactivity Disorder (ADHD) and highlights how there is a real ray of hope as recent advancements and better understanding of stem cells will make it possible to manage and treat several disorders, including ADHD.

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H.E. Dr Maryam Matar, MD, PhD
H.E. Dr Maryam Matar, MD, PhD
Her Excellency, Dr Matar is the Founder and Chairperson, UAE Genetic Diseases Association. She is a leading healthcare influencer, and pioneered the study of genes and advocates public education and awareness of genetic disorders across the ME region. She serves as a Chairperson/senior advisor in over 15 international, regional and local committees for preventive healthcare initiatives, women in STEM, and youth leadership. Dr Mater has been recognised as the most powerful scientist in the UAE since 2014; amongst the top 20 Arab scientists with the biggest contribution to humanity by British Scientific Community 2016; amongst the “top 100 most influential Arabs in the world” recognised by Arabian Business for four consecutive years since 2013.
H.E. Dr Maryam Matar, MD, PhD
H.E. Dr Maryam Matar, MD, PhD
H.E. Dr Maryam Matar, MD, PhD
Her Excellency, Dr Matar is the Founder and Chairperson, UAE Genetic Diseases Association. She is a leading healthcare influencer, and pioneered the study of genes and advocates public education and awareness of genetic disorders across the ME region. She serves as a Chairperson/senior advisor in over 15 international, regional and local committees for preventive healthcare initiatives, women in STEM, and youth leadership. Dr Mater has been recognised as the most powerful scientist in the UAE since 2014; amongst the top 20 Arab scientists with the biggest contribution to humanity by British Scientific Community 2016; amongst the “top 100 most influential Arabs in the world” recognised by Arabian Business for four consecutive years since 2013.

An overview of genes, obesity, and diabetes

H.E. Dr Maryam Matar discusses obesity and diabetes and how they can be influence by genes.

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View references

  1.  Latest Standards in Diabetes Medical Care. H.E. Dr. Maha Barakat. URL https://www.haad.ae/haad/tabid/58/Mid/417/ItemID/550/ctl/Details/Default.aspx
H.E. Dr Maryam Matar, MD, PhD
H.E. Dr Maryam Matar, MD, PhD
Her Excellency, Dr Matar is the Founder and Chairperson, UAE Genetic Diseases Association. She is a leading healthcare influencer, and pioneered the study of genes and advocates public education and awareness of genetic disorders across the ME region. She serves as a Chairperson/senior advisor in over 15 international, regional and local committees for preventive healthcare initiatives, women in STEM, and youth leadership. Dr Mater has been recognised as the most powerful scientist in the UAE since 2014; amongst the top 20 Arab scientists with the biggest contribution to humanity by British Scientific Community 2016; amongst the “top 100 most influential Arabs in the world” recognised by Arabian Business for four consecutive years since 2013.
H.E. Dr Maryam Matar, MD, PhD
H.E. Dr Maryam Matar, MD, PhD
H.E. Dr Maryam Matar, MD, PhD
Her Excellency, Dr Matar is the Founder and Chairperson, UAE Genetic Diseases Association. She is a leading healthcare influencer, and pioneered the study of genes and advocates public education and awareness of genetic disorders across the ME region. She serves as a Chairperson/senior advisor in over 15 international, regional and local committees for preventive healthcare initiatives, women in STEM, and youth leadership. Dr Mater has been recognised as the most powerful scientist in the UAE since 2014; amongst the top 20 Arab scientists with the biggest contribution to humanity by British Scientific Community 2016; amongst the “top 100 most influential Arabs in the world” recognised by Arabian Business for four consecutive years since 2013.

Peak performance and epigenetics

Her Excellency Dr Maryam Matar, MD, PhD, explains how peak performance is linked to epigenetics and enough scientific evidence is available to suggest that sleep, exercise, nutrition, and meditation impact on peak performance and health.

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H.E. Dr Maryam Matar, MD, PhD
H.E. Dr Maryam Matar, MD, PhD
Her Excellency, Dr Matar is the Founder and Chairperson, UAE Genetic Diseases Association. She is a leading healthcare influencer, and pioneered the study of genes and advocates public education and awareness of genetic disorders across the ME region. She serves as a Chairperson/senior advisor in over 15 international, regional and local committees for preventive healthcare initiatives, women in STEM, and youth leadership. Dr Mater has been recognised as the most powerful scientist in the UAE since 2014; amongst the top 20 Arab scientists with the biggest contribution to humanity by British Scientific Community 2016; amongst the “top 100 most influential Arabs in the world” recognised by Arabian Business for four consecutive years since 2013.
H.E. Dr Maryam Matar, MD, PhD
H.E. Dr Maryam Matar, MD, PhD
H.E. Dr Maryam Matar, MD, PhD
Her Excellency, Dr Matar is the Founder and Chairperson, UAE Genetic Diseases Association. She is a leading healthcare influencer, and pioneered the study of genes and advocates public education and awareness of genetic disorders across the ME region. She serves as a Chairperson/senior advisor in over 15 international, regional and local committees for preventive healthcare initiatives, women in STEM, and youth leadership. Dr Mater has been recognised as the most powerful scientist in the UAE since 2014; amongst the top 20 Arab scientists with the biggest contribution to humanity by British Scientific Community 2016; amongst the “top 100 most influential Arabs in the world” recognised by Arabian Business for four consecutive years since 2013.

Finding hope for ADHD through CRISPR/Cas9 genome editing

Her Excellency Dr Maryam Matar, MD, PhD, provides an overview of ADHD and discusses how CRISPR/Cas9 genome editing provides a ray of hope for ADHD.

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H.E. Dr Maryam Matar, MD, PhD
H.E. Dr Maryam Matar, MD, PhD
Her Excellency, Dr Matar is the Founder and Chairperson, UAE Genetic Diseases Association. She is a leading healthcare influencer, and pioneered the study of genes and advocates public education and awareness of genetic disorders across the ME region. She serves as a Chairperson/senior advisor in over 15 international, regional and local committees for preventive healthcare initiatives, women in STEM, and youth leadership. Dr Mater has been recognised as the most powerful scientist in the UAE since 2014; amongst the top 20 Arab scientists with the biggest contribution to humanity by British Scientific Community 2016; amongst the “top 100 most influential Arabs in the world” recognised by Arabian Business for four consecutive years since 2013.
H.E. Dr Maryam Matar, MD, PhD
H.E. Dr Maryam Matar, MD, PhD
H.E. Dr Maryam Matar, MD, PhD
Her Excellency, Dr Matar is the Founder and Chairperson, UAE Genetic Diseases Association. She is a leading healthcare influencer, and pioneered the study of genes and advocates public education and awareness of genetic disorders across the ME region. She serves as a Chairperson/senior advisor in over 15 international, regional and local committees for preventive healthcare initiatives, women in STEM, and youth leadership. Dr Mater has been recognised as the most powerful scientist in the UAE since 2014; amongst the top 20 Arab scientists with the biggest contribution to humanity by British Scientific Community 2016; amongst the “top 100 most influential Arabs in the world” recognised by Arabian Business for four consecutive years since 2013.

Cost effectiveness of population screening program in UAE

Her Excellency Dr Maryam Matar, MD, PhD, explains the cost effectiveness of population screening program in UAE. The screening is aimed at identifying thalassemia, sickle cell anemia, and G6PDH carriers.

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Dr Ravi Kanth
Dr Ravi Kanth
Dr Ravi Kanth is the Group Leader of genetics at the Asian Institute of Gastroenterology located at Hyderabad, Telangana, India.
Dr Ravi Kanth
Dr Ravi Kanth
Dr Ravi Kanth
Dr Ravi Kanth is the Group Leader of genetics at the Asian Institute of Gastroenterology located at Hyderabad, Telangana, India.

Non-alcoholic fatty liver disease: Does genetics have a role?

Non-alcoholic fatty liver disease (NAFLD) describes a range of conditions in the liver beginning with fatty liver (accumulation of fat), that may progress to non-alcoholic steatohepatitis (NASH – fat accumulation along with inflammation and scarring), cirrhosis (hepatic cells are replaced by scar tissue) and finally to Hepatocellular carcinoma (HCC). While conditions up to NASH are reversible, disease progression beyond NASH

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