The aim of this didactic article is to describe the implementation of a clinical outcomes registry within a clinical setting for musculoskeletal regenerative medicine. A patient-centred clinical registry, designed and implemented into the practice of a musculoskeletal clinic specializing in regenerative medicine.Read More.
Regenerative treatments are currently in active use to enhance many areas of orthopedic surgery in an attempt to improve success and outcome. In this review we provide a comprehensive overview of the peer-reviewed evidence-based literature, highlighting the clinical outcomes in humans both with preclinical data and human clinical trials involving regenerative preparations within the areas of rotator cuff, meniscus, ligament, and articular cartilage surgical repair.Read More.
There is a substantial need for new and emerging interventions for KOA for prevention and modiﬁcation of the disease process. This review will discuss current evidence of vitamins, minerals, hormones, genetics and their potential role in the progression and management of KOA. We aim to identify the modiﬁcations and considerations required in this aspect to improve the results of intra articular injections for regenerative medicine.Read More.
The purpose of this manuscript is to provide a current concept review for the rehabilitative management of knee osteoarthritis (KOA) following regenerative medicine intervention.Read More.
US is useful in various applications of regenerative medicine, starting from the biomaterial harvesting stage of the procedures, it can thus/conveniently be used for the diagnosis and treatment of various forms of knee osteoarthritis (OA) where the interventions need to be carried out under US guidance. In this paper, we have reviewed US guided bioharvesting of venous blood, bone marrow and adipose tissue, the US evaluation of the knee joint and the relevant ﬁndings in knee OA along with US guided regenerative interventions for the knee joint.Read More.
Regenerative medicine is an emerging discipline whose adherents aim to use the tools of the human body to address underlying dysfunction, leading to lasting repair of damaged tissues and structures. The evidence base lacks consensus on issues related to safety, efﬁcacy, cost-efﬁciency, and treatment speciﬁcations. In this current concepts review, we describe the potential impact of regenerative medicine for knee osteoarthritis and evaluate literature of the past decade for elements related to the quality of clinical research. Finally, we discuss strategies for improving the evidence base for the future.Read More.
Autologous mesenchymal stem cells (MSCs) have been utilized to treat degenerative and post-traumatic orthopedic conditions for more than two decades. Because MSCs can differentiate into bone, cartilage, muscle, tendon, and ligament tissue and can use paracrine and other effects to elicit significant changes in injured tissues, their use for treating orthopaedic conditions holds significant promise. The purpose of the present investigation is to report on detailed complications among a much larger group of 2372 orthopaedic patients treated with stem cell injections who were followed in a treatment registry for up to nine years.Read More.
H.E. Dr Maryam Matar provides an overview of Attention Deficit Hyperactivity Disorder (ADHD) and highlights how there is a real ray of hope as recent advancements and better understanding of stem cells will make it possible to manage and treat several disorders, including ADHD.Read More.
Dr. Asawari Bapat provides an in-depth article on regenerative medicine highlighting the opportunities for the Middle East. Regeneration considers the delivery of specific types of cells or cell products to the diseased tissues or organs, where they will ultimately restore the tissue and organ function. All this is done through cell-based therapy or by using cell products, such as growth factors.Read More.